Cleavable linkers in antibody–drug conjugates
نویسندگان
چکیده
منابع مشابه
Safety-Catch and Multiply Cleavable Linkers in Solid- Phase Synthesis
This review article focuses on concepts that incorporate safety-catch and multiply cleavable linkers in solid-phase synthesis. Discussed are specific applications of such linkers in the synthesis of peptides, peptide mimetics, and “small” organic molecules, as well as their limitations for particular chemistries and reaction conditions. © 1999 John Wiley & Sons, Inc. Biopoly 47: 353–363, 1998
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Labeling proteins with biotin is a widely used method to identify target proteins due to biotin's strong binding affinity for streptavidin. Combined with alkyne-azide cycloaddition, which enables the coupling of probes to targeted proteins, biotin tags linked to an alkyne or azide have become a powerful tool for purification and analysis of proteins in proteomics. However, biotin requires harsh...
متن کاملLinkers Having a Crucial Role in Antibody-Drug Conjugates.
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ژورنال
عنوان ژورنال: Chemical Society Reviews
سال: 2019
ISSN: 0306-0012,1460-4744
DOI: 10.1039/c8cs00676h